Hospital acquired infections are a major problem in medical care settings, resulting in prolonged hospital stays, increased treatment costs and in excess deaths. For a long time, HAI were deemed inevitable but nowadays, there is strong evidence that HAI are preventable by complying to hygienic standards. One crucial element to combat the endemic of healthcare-associated infections is being able to trace and track the transmission pathways of pathogens to develop effective interventions.
There is a lack of rapid tools to understand and monitor the spread of pathogens. Building on our previous work on DNA tracing technologies, we aim to develop tools and procedures to model and monitor the spread of pathogens without directly employing and measuring pathogens.
Project background
The goal of this project is to continue the development of synthetic surrogates of common pathogens with comparable physicochemical properties, especially susceptibility towards alcohol disinfection, stability upon desiccation and the ability to be transferred from one surface to another by touch. The use of DNA as a reporter molecule shall allow the use of the ultra-sensitive detection method of quantitative Polymerase Chain Reaction (qPCR). This method of detection will enable us to not only monitor the spread, but to additionally perform validations of hygiene protocols and other means of preventive measures.
We have set-up collaborations with major European hospitals to be able to test the synthetic surrogates developed in this project in real world scenarios.
Job description
- Formulating novel pathogen surrogates
- Comparing the novel surrogate stability and disinfectant susceptibility with real pathogens
- Discussing surrogate application and testing scenarios with medical professionals
- Collaborating with medical professionals in exposure scenario testing
- Develop new understandings on how pathogens spread and act
The tasks include wet-lab based experimentation, project management and teaching duties.
Position details:
- Start date: Jan. 1st 2026 or by agreement
- Funding: Fully funded PhD position (ca. 4 years, final admission to Doctoral Program after successful Aptitude Colloquium after 1.5 years, annual contract extensions)
